This may explain the development of endometrial adenocarcinoma in. The last menstrual period should be correlated with EMB results. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM. Additional and Relevant Useful Information for Benign Endometrial Hyperplasia: Endometrial cancer is a type of cancer that begins in the lining of the uterus (the endometrium). Definition focal overgrowth of localized benign endometrial tissue. The mean endometrial thickness measured on each day of the proliferation curve correlated closely with the mean estradiol levels measured on that day (coefficient 0. In the 2003 World Health Organization. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Learn more about the causes, diagnosis, and treatment of this condition. 1 To fulfil this latter role, the endometrium is unique in that it undergoes cyclical epithelial and stromal morphogenesis during the reproductive years. does scant superficial strips of inactive endometrium seperate fragments of unremarkable squamous epithelium & mucus mean on an endometrial biops? 1 doctor answer • 2 doctors. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. Smith et al 16 reported that 348 of 1832 women (19%) with PMB had “functional endometria” in their initial evaluation of PMB. Family Medicine 49 years experience. 04, 95% CI 2. I'm sure your physician is monitoring your endometrial lining via biopsy or D&C to make sure that you aren't at increased risk of endometrial hyperplasia or pre-cancer of the endometrium. 11. 1 The American College of Obstetricians and Gynecologists (ACOG) recommends endometrial tissue sampling in any woman with abnormal uterine bleeding who is older than 45 years, or in. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts. 4% Disordered Proliferative Endometrium 82 7. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. [10]: (1) constant appearance of basalis throughout the menstrual cycle, (2) glands of the basalis appear weakly proliferative, (3) basalis cells lack secretory features and the stroma is spindled. read moreSpecimens A. The immunohistochemical staining pattern for CD138 with appr. General Surgeon. Demosthenes, MD. The unstained glands are irregularly dispersed with focal back-to-back crowding. Definition and Classification. Screening for endocervical or endometrial cancer. Atrophic endometrial tissue is smaller than normal endometrial tissue and has lost some of its function. EMCs. Read More. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The polyp sticks out from the thin layer of tissue on the inside uterus called the endometrium. 8% of hysteroscopies and in 56. Definition and Classification. At least she chatted to you as much as possible about the results. Harold Fields answered. Can be pedunculated or sessile, single or multiple, and up to many centimeters in size. The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. Deborah Josefson: Excess estrogen : This is suggestive of an increased estrogen state an. There was one case who was a 75-years-old woman presenting with both deep infiltrating endometriosis in bladder and small bowel and adenomyosis lesions, but her endometrium was weakly proliferative. 04, 95% CI 2. "My gynecologist did the biopsy to rule out uterine cancer (which neither of us thought I had), as we try to determine the cause of my dysfunctional uterine bleeding. 0 x 0. The 2024 edition of ICD-10-CM N85. The presence of weakly proliferative endometrium in high risk women with PMB for endometrial adendocarcinoma hysterectomy may be indicated especially if follow-up of the patient is difficult. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. Doctoral Degree. Bleeding after menopause. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. May be day 5-13 - if the menstruation is not included. When cancer grows in this lining, it is called. "what does it mean? inactive endometrium with focal tubal metaplasia? benign endometrial polyp. Decidua and decidualization redirect to this article. Because atrophic postmenopausal endometrium is no longer active, there are few or no mitotic cells. 9 vs 30. I had an endometrial biopsy 10 days ago and just received the results in the mail. An endometrial polyp was found in 86. Hence, it is also known as Metaplastic Changes in Endometrial Glands. 78% cases) and. 1,762. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown. Wechat. Created for people with ongoing healthcare needs but benefits everyone. You might want to discuss low dose oral bcp's with your gyn or get a second opinion, as the bcp's stop all ovarian. How is proliferative endometrium treated? Endometrial hyperplasia treatment The most. There is a clinically insignificant 16% pathologic underdiagnosis rate. 1 The American College of Obstetricians and Gynecologists (ACOG) recommends endometrial tissue sampling in any woman with abnormal uterine bleeding who is older than 45 years, or in. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. In your case, there could be no enough progesterone to organize the proliferation caused by the estrogen and when the phase of secretion. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. Open in a separate window. Endometrial polyps are common and usually benign. Your provider can also use endometrial. Note that when research or. This pictorial review takes you through the hysteroscopic view of normal-looking. Compact. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. Blood. 25% of patients with endometrial cancer had a previous benign EMB/D&C. A menstrual cycle for one woman may last for a few days but for another woman may last a. The study of endometrial carcinoma at menopause presents an interesting challenge. Share. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. -- abundant neutrophils and blood. SEE COMMENT. The asymptomatic disease free postmenopausal endometria derived from the prolapsed uteruses were atrophic and inactive in 42 of the 84 women, atrophic and weakly proliferative in 22, and of mixed form in 20 women. This protocol is in agreement with that of Dimitraki et al. The pathology breakdown showed: AE. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. 5% Menstrual Endometrium 52 5. Created for people with ongoing healthcare needs but benefits everyone. 10 ) [ 1 , 10 , 11 ]. Can be pedunculated or sessile, single or multiple, and up to many centimeters in size. leiomyoma, other polypoid masses. This highly regenerative capacity is likely driven by stem/progenitor cell populations that reside in the basalis. Pathology 51 years experience. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. endometrium, aspiration: - fragments of predominant inactive, very weakly proliferative endometrial epithelium attached to a very small amount of unremarkable stroma. Not having a period (pre-menopause)The degree of proliferative activity can usually be assessed by the mitotic activity in both the glandular epithelium and the stroma. Thank. Localized within the uterine wall, extends into the uterine cavity. Endometritis is inflammation of the endometrium (the inner lining of your uterus) due to infection. Disordered proliferative endometrium with glandular and. 5 to 7–8 mm during the mid-proliferative phase ( 17 ). This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. read more. Endometrial receptivity describes the intricate process undertaken by the uterine lining to prepare for the implantation of an embryo. Compact. Definition / general. Cytoplasmic vacuoles become supranuclear and secretions are seen within glandular lumina (Fig. Created for people with ongoing healthcare needs but benefits everyone. Best would be to contact the pathologist who wrote the report. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called endometrial hyperplasia. Women with a proliferative endometrium were younger (61. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). . It’s not cancer, but in certain women, it raises the risk of developing endometrial cancer, a type of uterine cancer. 1097/AOG. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. A repeat "d&c after ablation " is usually not going to produce different results. Exogenous hormones taken for various reasons may have an effect on the morphology of endometrium, endometrial stroma and myometrial lesions, such as leiomyomas. 72 mm w/ polyp. A "d&c" which is reported as "scant glandular endometrium " is a benign pathological condition. Methods. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. 0001) and had a higher body mass index (33. What does this test result mean. Main. It says "weakly proliferative with stromal breakdown, negative for hyperplasia or carcinoma. The study of endometrial carcinoma at menopause presents an interesting challenge. Even if the 50% (1:1) cutoff is the most practical from a diagnostic and clinical perspective, what. 00 became effective on October 1, 2023. 2 percent) Hyperplasia without atypia (2 percent) Hyperplasia with atypia (0. Specimen was received in formalin and consists of mucoid. 6 kg/m 2; P<. Proliferate definition: . Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. Gurmukh Singh answered. 11. MD. 4. It refers toAn endometrial polyp was found in 86. 2. Dr R. 0001) and had a higher body mass index (33. 09–7. A Verified Doctor answered. Objective: This study aimed to report on the long-term outcome of postmenopausal women who received a diagnosis of proliferative endometrium. Mixed: The mixed form of endometrium is defined as atrophic and inactive endometria showing focal areas of weakly proliferative glands. This pattern is sometimes seen in women with dysfunctional bleeding Progestational Agents Marked pseudo-decidualization of stroma. Women with a proliferative endometrium were younger (61. What does this mean? waiting to hear from doctor. MD. Is this a diagnosable condition? Proliferative endometrium isn't a symptom or condition. 5%. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. It may be associated with abnormal menstrual bleeding or infertility. or weakly proliferative (P=0. Then ovulation occurs. The spectrum of. , from endogenous sources such as obesity or from. What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without hyperplasia or malignancy. Hormonal imbalances: Hormonal imbalances, such as decreased levels of estrogen and progesterone, can contribute to the endometrium. read more. , proliferative endometrium. 5 ±17. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. The basic effect of estrogens on the endometrium is to induce proliferation of the endometrial glands and stroma, including vascular endothelium. Applicable To. 09–7. Limitation of this study is the small number of cases studied. My interpretation is that the pathologist saw fragments of endometrium in the proliferative phase, in contrast to the secretory phase. ), 19% premalignant lesions, and. During the menstrual cycle, the endometrium grows under the influence of two major hormones estrogen and progesterone. 5 ±17. Two thirds of proliferative endometrium with breakdown showed plasma cells (19% grade 1, 39% grade 2, 10 % grade 3). The stromal cells are arranged in a compact manner. Created for people with ongoing healthcare needs but. Dr. Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferative Endometrial hyperplasia Asynchronously developed endometrium. No apparent endometrial hyperplasia was seen. New blood vessels develop and the endometrial glands become bigger in size. Location: Needham,MA. 8% of hysteroscopies and in 56. Medical Director. Proliferative endometrium isn’t a symptom or condition. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. Female Genital Pathology. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). No apparent endometrial hyperplasia was seen. 3,246 satisfied customers. Bleeding between periods. The physiologic changes of the endometrium during reproductive life and after menopause reflect the influence of ovarian-secreted steroid sex hormones and of their withdrawal. Endometrial metaplasia can be associated with hyperestrogenism, inflammation, repeated irritation or endometrial polyps. This is healthy reproductive cell activity. and 200 cases of endometrial samples with typical tubal metaplasia were followed for a mean of 64 and 61 months, respectively. My endometrial biopsy says "small fragments of weakly proliferative type endometrum admixed with abundant mucus" I am currently on an OCP. This condition is detected through endometrial biopsy. Pediatrics 35 years experience. 8 became effective on October 1, 2023. what does that mean? 1 doctor answer • 1 doctor weighed inWhat do these endometrial biopsy results mean:diagnosis: endometrium, biopsy - scant strips of inactive glandular epithelium admixed with inflamed mucus, keratin debris and blood. 2). endometrial intraepithelial neoplasia (EIN). What do the results of my endometrial biopsy mean? Here are some words and phrases you might see on your biopsy results: Proliferative endometrium; Atrophic endometrium ; Hyperplasia; Carcinoma; If you see either of the first two phrases, your results are normal. 2 vs 64. A hysterectomy stops symptoms and. 8% of all surgical specimens of women with PE. The impact of the endometrial proliferative phase on human embryo implantation remains unclear, but deserves further attention, especially since in luteal phase endometrial biopsies, a transcriptional signature predictive for repeated implantation failure has been associated with reduced cell proliferation, possibly indicating proliferative. Ultrasound(pelvic and trans vaginal) that homogeneous endometrium is seen measuring 5 - 6 mm. 81, p < 0. Included were 18 cases (55%) diagnosed within the first year and presumed concurrent, and an. The prevalence of endometriosis in reproductive-aged women is 2% to 10%, while in those who have been through menopause, the prevalence is an estimated 2. Hysteroscopy combined with biopsy increases the accuracy of diagnosis up to 100%. 9 and 12. The non-neoplastic endometrium adjacent to an endometrial adenocarcinoma was active in 43 of the 50 women; four. 7% cases and weakly proliferative endometriumDefinition. The epithelium is columnar, with only a minor degree. Stroma is made up of cells that give the tissue its strength and shape. In evaluating an endometrial biopsy specimen, an adequate clinical history is important, including the age of the patient and the reason for the biopsy. This pattern may be seen in the perimenopausal years, or in postmenopausal years if there is a source of at least low-level estrogenic stimulation (e. Symptoms. 1,758 satisfied customers. doi: 10. Before treatment, 56 subjects (60%) had an endometrial biopsy with findings classified as weakly proliferative or proliferative. An introduction to the endometrium is found in the endometrium article. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). Learn how we can help. Conditions that involve the endometrium and may impact fertility include: Adenomyosis. Adenofibromas most commonly occur in postmenopausal women but the age range is wide. New blood vessels develop and the endometrial glands become bigger in size. The mean follow. Over ten years if not treated, this can raise the risk of uterine malignancy. The pathologist must be aware of the spectrum of endometrial metaplasias encountered and the clinical setting in which they. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Created for people with ongoing healthcare needs but benefits everyone. Disordered proliferative endometrium with glandular and. An endometrial biopsy is generally performed in cases of 'dysfunctional uterine bleeding' - meaning, bleeding that is heavy, irregular, or otherwise. 0–3. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. What. Markedly atypical nuclei identical to those of invasive serous carcinomas, lining the surfaces and glands of an atrophic endometrium. Endometrium, EMC Final Diagnosis A. 5 years; P<. stroma. Keywords: endometrium, atrophic, inactive, weakly proliferative, endometrial adenocarcinoma. Doctor's Assistant: When was your last pap smear? Have you ever had an irregular pap? My pap was good clinical history is abnormal uterine bleeding. Absence of uterine bleeding. These symptoms can be uncomfortable and disruptive. Afte. Learn how we can helpClin. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. your doctor should check your estrogen and LH and FSH hormone levels to see if they are normal. The presence of weakly proliferative endometrium in high risk women with PMB for endometrial adendocarcinoma hysterectomy may be indicated especially if. Proliferative Endometrium Variably/haphazardly shaped glands (e. While secretory changes in endometrial glands can be observed occasionally at birth, decidual or menstrual changes are rare ( 25 ). They consist of proliferative endometrium (sometimes weakly proliferative), often with stromal breakdown, and/or of endometrial hyperplasia. A hysterectomy makes it impossible for you to become pregnant in the future. It can be healthy or disordered depending on the rate of cell growth and shedding. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. Postmenopausal bleeding. Early diagnosis and treatment of EH (with or without atypia) can prevent progression to. 0% Exogenous. BIOPSY. Your healthcare provider may suggest an endometrial biopsy if you have: Abnormal menstrual bleeding. Biopsy results may show cell changes linked to hormone levels, or abnormal tissues, such as fibroids or polyps. 5. Blood. Diagnosis: Fragments of weakly proliferative/inactive endometrium. They described functional endometrium as being “weakly proliferative” or “weakly. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. I. Too thin or too thick endometrium. tubal/eosinophil hyperpla A Verified Doctor answered Dr. « lining in uterus thickened | Cells from uterus that show up in a pap ». We distinguished basalis endometrium from functionalis endometrium by defined histological criteria as described previously by Hendrickson et al. Conclusion One in six postmenopausal women who underwent endometrial sampling had proliferative endometrium. See examples of PROLIFERATE used in a sentence. Decidualization may be seen in a. Dr. 1 Characterized by ciliated columnar cells with bland round nuclei and eosinophilic cytoplasm, similar to the cells. 4) and their mean BMI was 31. What does disordered proliferative endometrium mean? Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. It's normal and usually means you can avoid major surgery if you have bleeding. Clin. Proliferative endometrium refers to the time during the menstrual cycle when a layer of cells is being prepared for a fertilized egg to attach to. the expression of Bcl-2 in the proliferative phase polyps in both the glandular epithelium and stroma compared with. Learn how we can help. Adenofibromas most commonly occur in postmenopausal women, but the age range is wide. It is a physiological response seen in pregnancy. Note that when research or. SEE COMMENT. This pattern may be seen in the perimenopausal years, or in postmenopausal years if there is a source of at least low-level estrogenic stimulation (e. Changes at the lower end of the histological spectrum are referred to as “disordered proliferative endometrium” (DPE), which describes a proliferative endometrium (PE) lacking the usual regularity of gland size and spacing. The endometrium is obtained for evaluation by a process called dilatation and curettage or by endometrial biopsy. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk. Proliferative endometrium is part of the female reproductive process. During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. More African American women had a. Epub 2023 Jan 4. received endo biopsy result of secretory, focally inactive endometrium, neg for hyperplasia and malignancy. 09–7. 00 may differ. Definition. However, in some instances, they cause pain, irregular bleeding, or infertility. Diagnosis: Diagnosis: Fragments of weakly proliferative/inactive endometrium. Created for people with ongoing healthcare needs but benefits everyone. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE. - Negative for polyp, hyperplasia, atypia or. Unremarkable squamous epithelium is also normal and mucus is a normal finding. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Endometrial biopsy was performed 3 to 4 weeks after completion of therapy to assess response. Uterine polyp and endometrial polyp redirect here. Ed Friedlander and 4 doctors agree. Oral contraceptives (OCs) containing a low-dose, low-potency progesterone and low-dose estrogen stop proliferation of the glands during the 1st few cycles and the glands are. It is a normal finding in women of reproductive age. (b) On CD10 immunohistochemistry, the stroma stains positive, confirming endometrial-type stroma, while the endometrial glands are negative. Learn how we can help. This is the American ICD-10-CM version of N85. read more. Weakly proliferative endometrium shows a pattern intermediate between normal proliferative and atrophic. During menopause, the ovaries produce fewer hormones, leading to a cessation of the menstrual cycle. Indeed polyps, adenomyosis, and leiomyomas have all been associated with an increased likelihood of abnormal endometrial molecular expressions thought to impair implantation and early embryo development. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. Your GP probably hadn't had time or knowledge that the report was ready to read. These sound like the results from an endometrial biopsy - basically, when your doctor takes a clipping or scraping from inside the uterus and sends it off to a pathologist to be examined. Images of. -- balls of condensed endometrial stroma. Learn about the causes, symptoms,. Initial evaluation — The primary goal in the diagnostic evaluation of postmenopausal patients with uterine bleeding is to exclude. 9. The endometrial tissue is a sensitive target for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility. (female) Join Date: Nov 2007. Read More. ICD-10-CM Coding Rules. 25% of patients with endometrial cancer had a previous benign EMB/D&C. (2) Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. In this phase, tubular glands with columnar cells and surrounding dense stroma are proliferating to build up the endometrium following shedding with previous. Endometrial cancer is sometimes called uterine cancer. What layer of the endometrium is shed during the. What does weakly proliferative endometrium mean. Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. However, in some instances, they cause pain, irregular bleeding, or infertility. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. Endometriosis often involves the pelvic tissue. Does proliferative endometrium mean cancer? No. We performed p16 immunostaining on 35 normal endometrial specimens and 32 EPs, six of which were associated with tamoxifen therapy. Microscopic findings. Lindemann. General Surgeon. The mean age at which the patients were. If the estrogen dose is low, there may also be a lesser degree of proliferation that is described as weakly proliferative. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. Methods. Endometrial biopsies can help identify the presence of these types of abnormal tissues. Decidualized stromal cells are derived from the fibroblast-like cells within the endometrium, which maintain their progesterone receptors in the presence of progesterone. This book chapter provides an overview of the epidemiology, risk factors, diagnosis, staging, and treatment of endometrial cancer, as well as the latest research and guidelines. As a result, the endometrium becomes thin and atrophic, displaying characteristics of inactivity. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 1%) a mixture of non-secretory and secretory endometrium. We compared EE as a surrogate for an estrogen milieu with Atrophic Endometrium (AE) as a surrogate for the absence of estrogen milieu. Endometrial carcinomas account for the greatest number of these cases, as fewer than 10% of uterine corpus cancers are sarcomas. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. g. Endometrial polyps are common and usually benign. Furthermore, 962 women met the inclusion criteria. These can lead to abnormal bleeding. Normal: Your endometrial lining was in the proliferative phase of the menstrual cycle. It can affect nearby organs, including the bowel and bladder. 00524, p <0. 5.